We identify the a and b of the pattern.

In our pattern, a=2x and b=−3y.
We use the Binomial Theorem.
(a+b)n=(n0)an+(n1)an−1b1+(n2)an−2b2+...+(nr)an−rbr+...+(nn)bn
Substitute in the values a=2x, b=−3y and n=4.
(2x−3y)4=(40)(2x)4+(41)(2x)4−1(−3y)1+(42)(2x)4−2(−3y)2+(43)(2x)4−3(−3y)3+(44)(−3y)4
Simplify the exponents.
(2x−3y)4=(40)(2x)4+(41)(2x)3(−3y)1+(42)(2x)2(−3y)2+(43)(2x)1(−3y)3+(44)(−3y)4
Evaluate the coefficients. Remember, (n1)=n,(nn)=1,(n0)=1.
(2x−3y)4=1(2x)4+4(2x)3(−3y)1+2!(2)!4!(2x)2(−3y)2+3!(4−3)!4!(2x)1(−3y)3+1(−3y)4
(2x−3y)4=16x4+4⋅8x3(−3y)+6(4x2)(9y2)+4(2x)(−27y3)+81y4
(2x−3y)4=16x4−96x3y+216x2y2−216xy3+81y4